Analysis of 5hk5H

cluster	n	neff	AF2_TM1	AF2_TM2	AF3_TM1	AF3_TM2	RE-MSAT-COM	RE-MSAT1	RE-MSAT2	ESM_SEQIDS	ESM_TM1_LIST	ESM_TM2_LIST
Deep	-	-	0.7	0.74	0.64	0.74	0.51	0.48	0.47	-	-	-
000	-	-	0.6	0.63	0.49	0.47	0.2	0.19	0.19	001; 001; 002; 002; 009; 009; 004; 004; 005; 005	0.61; 0.61; 0.60; 0.60; 0.55; 0.55; 0.54; 0.54; 0.54; 0.54	0.55; 0.55; 0.58; 0.58; 0.54; 0.54; 0.51; 0.51; 0.52; 0.52
001	-	-	0.32	0.34	0.39	0.37	0.02	0.01	0.01	002; 002; 010; 010; 009; 009; 001; 001; 003; 003	0.60; 0.60; 0.58; 0.58; 0.55; 0.55; 0.55; 0.55; 0.49; 0.49	0.58; 0.58; 0.56; 0.56; 0.52; 0.52; 0.54; 0.54; 0.49; 0.49
002	-	-	0.32	0.34	0.39	0.38	0.0	0.0	0.0	002; 002; 010; 010; 009; 009; 001; 001; 003; 003	0.60; 0.60; 0.58; 0.58; 0.55; 0.55; 0.55; 0.55; 0.49; 0.49	0.58; 0.58; 0.56; 0.56; 0.52; 0.52; 0.54; 0.54; 0.49; 0.49
003	-	-	0.62	0.68	0.68	0.74	0.0	0.0	0.0	002; 002; 003; 001; 003; 001; 010; 010; 005; 005	0.66; 0.66; 0.65; 0.65; 0.65; 0.65; 0.63; 0.63; 0.60; 0.60	0.70; 0.70; 0.66; 0.66; 0.65; 0.66; 0.64; 0.64; 0.62; 0.62
004	-	-	0.64	0.7	0.64	0.72	0.0	0.0	0.0	001; 001; 005; 004; 005; 004; 007; 007; 006; 006	0.68; 0.68; 0.62; 0.62; 0.62; 0.62; 0.56; 0.56; 0.55; 0.55	0.70; 0.70; 0.65; 0.67; 0.65; 0.67; 0.66; 0.66; 0.56; 0.56
005	-	-	0.58	0.62	0.59	0.61	0.0	0.0	0.0	008; 008; 003; 003; 010; 005; 001; 005; 001; 009	0.59; 0.59; 0.58; 0.58; 0.56; 0.56; 0.56; 0.56; 0.56; 0.56	0.59; 0.59; 0.59; 0.59; 0.58; 0.58; 0.58; 0.58; 0.58; 0.58
006	-	-	0.37	0.4	0.34	0.37	0.2	0.18	0.24	002; 002; 003; 003; 010; 009; 010; 009; 006; 006	0.60; 0.60; 0.59; 0.59; 0.58; 0.58; 0.58; 0.58; 0.55; 0.55	0.58; 0.58; 0.60; 0.60; 0.56; 0.56; 0.56; 0.56; 0.53; 0.53
007	-	-	0.55	0.52	0.49	0.54	0.0	0.0	0.0	009; 009; 008; 008; 006; 006; 001; 001; 007; 007	0.66; 0.66; 0.63; 0.63; 0.61; 0.61; 0.58; 0.58; 0.58; 0.58	0.69; 0.69; 0.67; 0.67; 0.64; 0.64; 0.56; 0.56; 0.56; 0.56
008	-	-	0.52	0.55	0.55	0.58	0.0	0.0	0.0	008; 008; 006; 007; 006; 007; 003; 001; 003; 001	0.62; 0.62; 0.60; 0.60; 0.60; 0.60; 0.59; 0.59; 0.59; 0.59	0.64; 0.64; 0.67; 0.63; 0.67; 0.63; 0.63; 0.63; 0.63; 0.63
009	-	-	0.58	0.6	0.53	0.57	0.02	0.02	0.02	004; 004; 007; 007; 006; 006; 001; 002; 009; 001	0.66; 0.66; 0.61; 0.61; 0.59; 0.59; 0.56; 0.56; 0.56; 0.56	0.66; 0.66; 0.62; 0.62; 0.61; 0.61; 0.59; 0.60; 0.58; 0.59
010	-	-	0.64	0.71	0.64	0.69	0.1	0.09	0.08	003; 003; 007; 007; 008; 008; 002; 002; 001; 001	0.64; 0.64; 0.61; 0.61; 0.60; 0.60; 0.58; 0.58; 0.56; 0.56	0.62; 0.62; 0.60; 0.60; 0.64; 0.63; 0.61; 0.61; 0.58; 0.58
011	-	-	0.59	0.61	0.57	0.61	0.0	0.0	0.0	005; 005; 002; 002; 001; 001; 007; 007; 006; 006	0.62; 0.62; 0.61; 0.61; 0.59; 0.59; 0.58; 0.58; 0.58; 0.58	0.63; 0.63; 0.65; 0.64; 0.61; 0.61; 0.62; 0.62; 0.62; 0.62
012	-	-	0.58	0.6	0.53	0.57	-	-	-	004; 004; 007; 007; 006; 006; 001; 002; 009; 001	0.66; 0.66; 0.61; 0.61; 0.59; 0.59; 0.56; 0.56; 0.56; 0.56	0.66; 0.66; 0.62; 0.62; 0.61; 0.61; 0.59; 0.60; 0.58; 0.59
013	-	-	0.57	0.61	0.57	0.61	-	-	-	004; 005; 004; 005; 008; 010; 010; 008; 003; 003	0.61; 0.61; 0.61; 0.61; 0.60; 0.60; 0.60; 0.60; 0.58; 0.58	0.64; 0.63; 0.64; 0.63; 0.65; 0.61; 0.61; 0.65; 0.62; 0.62
014	-	-	0.59	0.61	0.57	0.61	-	-	-	005; 005; 002; 002; 001; 001; 007; 007; 006; 006	0.62; 0.62; 0.61; 0.61; 0.59; 0.59; 0.58; 0.58; 0.58; 0.58	0.63; 0.63; 0.65; 0.64; 0.61; 0.61; 0.62; 0.62; 0.62; 0.62

Aligned per-residue ΔΔG

aln_pos	aa1	aa2	E1	E2	dEdiff
1	P	-	12.13	-	-
2	A	-	5.22	-	-
3	G	-	1.29	-	-
4	A	-	-1.42	-	-
5	I	-	0.71	-	-
6	P	-	17.94	-	-
7	S	-	0.88	-	-
8	P	-	2.24	-	-
9	Y	-	28.49	-	-
10	W	-	18.64	-	-
11	H	H	9.61	3.79	5.82
12	H	H	1.91	1.51	0.4
13	Q	Q	2.5	4.34	-1.83
14	I	I	1.11	2.83	-1.72
15	K	K	4.62	3.68	0.94
16	E	E	1.36	9.29	-7.93
17	V	V	4.24	2.99	1.25
18	L	L	-4.28	-4.98	0.7
19	A	A	1.38	0.13	1.25
20	S	S	1.16	4.81	-3.65
21	S	S	2.75	2.09	0.67
22	Q	Q	11.85	8.9	2.94
23	E	E	5.28	1.08	4.21
24	A	A	3.11	-3.11	6.22
25	L	L	0.94	2.53	-1.59
26	V	V	-0.76	2.25	-3.01
27	V	V	-3.55	3.82	-7.37
28	T	T	0.21	2.26	-2.05
29	E	E	-0.82	0.62	-1.44
30	R	R	-1.48	8.98	-10.46
31	K	K	4.82	7.45	-2.64
32	Y	Y	2.16	-2.41	4.58
33	L	L	-1.75	1.28	-3.03
34	K	K	4.51	3.97	0.54
35	S	S	3.94	0.21	3.73
36	D	D	-0.53	3.57	-4.1
37	W	W	1.43	-2.21	3.64
38	C	C	1.92	-0.88	2.8
39	K	K	1.65	-0.73	2.38
40	T	T	6.77	-1.05	7.82
41	Q	Q	2.96	-0.72	3.67
42	P	P	-0.25	0.8	-1.05
43	L	L	-1.71	-3.29	1.59
44	R	R	0.43	1.07	-0.63
45	Q	Q	1.93	-1.72	3.65
46	T	T	-0.33	0.38	-0.71
47	V	V	-2.81	-4.47	1.66
48	S	S	0.52	-1.54	2.06
49	E	E	9.42	2.65	6.77
50	E	E	7.11	5.51	1.6
51	G	G	0.08	-3.04	3.11
52	C	C	1.0	1.01	-0.01
53	R	R	4.05	7.94	-3.89
54	S	S	0.38	-0.88	1.25
55	R	R	3.68	-2.78	6.47
56	T	T	-0.93	-0.09	-0.84
57	I	I	3.94	0.11	3.82
58	L	L	7.18	0.71	6.46
59	N	N	-2.5	-4.11	1.61
60	R	R	9.98	0.05	9.92
61	F	F	-2.97	-5.51	2.54
62	C	C	-2.02	-2.11	0.09
63	Y	Y	-2.57	-2.88	0.31
64	G	G	-0.67	-3.19	2.52
65	Q	Q	-1.27	-3.38	2.11
66	C	C	-0.65	0.12	-0.78
67	N	N	-1.57	-2.34	0.78
68	S	S	-1.61	-2.71	1.1
69	F	F	-3.08	6.58	-9.66
70	Y	Y	-2.61	-3.21	0.6
71	I	I	-1.06	-3.87	2.81
72	P	P	-3.12	-4.4	1.28
73	R	R	6.8	3.4	3.4
74	H	H	3.3	0.78	2.51
75	V	V	4.79	-0.94	5.72
76	K	K	17.21	16.57	0.64
77	K	K	12.05	1.59	10.47
78	E	E	9.13	2.75	6.38
79	E	E	11.03	3.25	7.78
80	D	D	11.62	2.07	9.55
81	S	S	2.02	-0.43	2.45
82	F	F	-0.79	11.32	-12.11
83	Q	Q	-0.29	1.21	-1.5
84	S	S	-1.06	-1.5	0.44
85	C	C	1.19	3.1	-1.91
86	A	A	-0.98	-1.69	0.71
87	F	F	1.51	-1.44	2.96
88	C	C	-2.09	-2.26	0.17
89	K	K	1.03	0.9	0.13
90	P	P	-3.32	-5.86	2.53
91	Q	Q	3.8	2.7	1.1
92	R	R	11.06	6.05	5.0
93	V	V	1.75	2.89	-1.15
94	T	T	1.11	0.25	0.86
95	S	S	2.4	13.75	-11.35
96	V	V	-0.64	1.01	-1.66
97	I	I	1.39	3.11	-1.72
98	V	V	1.63	-4.63	6.26
99	E	E	9.57	-1.06	10.63
100	L	L	1.15	-4.82	5.97
101	E	E	4.07	-1.34	5.42
102	C	C	11.0	0.8	10.2
103	P	P	7.33	-0.12	7.46
104	G	G	0.62	-0.02	0.64
105	L	L	6.76	-2.38	9.14
106	D	D	17.43	1.57	15.86
107	P	P	8.27	-2.58	10.85
108	P	P	0.48	-5.97	6.45
109	F	F	-0.26	-0.73	0.47
110	R	R	3.21	-1.61	4.81
111	I	I	4.37	4.97	-0.6
112	K	K	11.3	9.1	2.19
113	K	K	2.94	7.6	-4.66
114	I	I	-0.02	-1.27	1.25
115	Q	Q	1.13	-0.06	1.19
116	K	K	14.96	-1.92	16.88
117	V	V	-3.46	-4.16	0.7
118	K	K	7.5	1.19	6.32
119	H	H	-0.51	0.73	-1.24
120	C	C	-1.75	-1.91	0.15
121	R	R	0.38	1.64	-1.26
122	C	C	-0.34	1.5	-1.84
123	M	M	-1.25	0.81	-2.06
124	S	S	-1.97	0.59	-2.56
125	V	V	-0.9	4.29	-5.19
126	N	-	0.58	-	-
127	L	-	3.23	-	-
128	S	-	2.36	-	-
129	P	-	5.42	-	-
130	A	-	1.65	-	-
131	G	-	0.25	-	-
132	A	-	-0.32	-	-
133	I	-	8.7	-	-
134	P	-	21.09	-	-
135	S	-	2.0	-	-
136	P	-	-0.74	-	-
137	Y	-	2.02	-	-
138	K	-	12.25	-	-
139	W	-	15.77	-	-
140	H	-	6.15	-	-
141	H	-	1.35	-	-
142	Q	-	3.01	-	-
143	I	-	5.04	-	-
144	-	X	-	0.89	-
145	-	X	-	-0.64	-
146	-	X	-	3.46	-
147	-	X	-	0.23	-
148	-	X	-	0.76	-
149	-	X	-	6.49	-
150	K	K	6.85	4.24	2.61
151	E	E	1.29	7.19	-5.9
152	V	V	4.15	0.16	3.99
153	L	L	1.58	9.06	-7.48
154	A	A	3.18	-0.01	3.19
155	S	S	0.58	-0.8	1.39
156	S	S	2.23	-0.72	2.95
157	Q	Q	11.88	5.15	6.73
158	E	E	5.26	0.24	5.02
159	A	A	2.55	-4.52	7.07
160	L	L	3.5	-1.78	5.28
161	V	V	1.17	1.38	-0.21
162	V	V	-1.15	-2.26	1.12
163	T	T	1.82	-1.45	3.27
164	E	E	-0.06	-0.51	0.45
165	R	R	2.16	18.31	-16.15
166	K	K	4.83	1.78	3.05
167	Y	Y	0.31	0.87	-0.55
168	L	L	1.36	-2.28	3.64
169	K	K	15.82	4.75	11.07
170	S	S	4.4	1.68	2.72
171	D	D	-0.5	2.18	-2.68
172	W	W	1.69	-2.38	4.07
173	C	C	1.85	-1.05	2.9
174	K	K	9.51	-0.58	10.09
175	T	T	9.2	-1.01	10.2
176	Q	Q	3.39	0.71	2.68
177	P	P	0.4	0.71	-0.31
178	L	L	-4.24	-1.04	-3.2
179	R	R	1.26	5.26	-4.0
180	Q	Q	2.24	1.79	0.45
181	T	T	0.22	-2.38	2.6
182	V	V	-2.53	-5.33	2.8
183	S	S	6.29	-0.69	6.98
184	E	E	1.44	-1.1	2.54
185	E	E	3.71	1.49	2.22
186	G	G	-0.13	-3.28	3.15
187	C	C	0.94	-0.1	1.04
188	R	R	5.24	4.64	0.6
189	S	S	8.38	-0.44	8.82
190	R	R	4.1	-2.37	6.47
191	T	T	0.34	-0.92	1.25
192	I	I	3.08	-1.0	4.08
193	L	L	7.89	6.12	1.77
194	N	N	-2.78	-1.25	-1.53
195	R	R	7.86	0.86	7.0
196	F	F	-3.91	-6.16	2.25
197	C	C	-2.61	-1.44	-1.17
198	Y	Y	-2.82	-3.3	0.48
199	G	G	-0.57	-2.36	1.79
200	Q	Q	-1.49	-3.44	1.95
201	C	C	-0.51	0.33	-0.84
202	N	N	-2.0	-1.47	-0.53
203	S	S	-2.25	-4.14	1.89
204	F	F	-1.75	-5.26	3.5
205	Y	Y	-1.47	-3.17	1.7
206	I	I	-3.58	-2.55	-1.04
207	P	P	-4.88	-4.5	-0.39
208	R	R	4.02	9.16	-5.14
209	H	H	2.53	8.61	-6.08
210	V	V	5.17	2.83	2.34
211	K	K	18.37	4.76	13.61
212	K	K	9.18	3.49	5.69
213	E	E	7.2	0.71	6.49
214	E	E	1.21	9.74	-8.53
215	D	D	3.5	12.93	-9.43
216	S	S	-1.78	-0.22	-1.56
217	F	F	1.0	-0.11	1.11
218	Q	Q	-2.03	-0.24	-1.79
219	S	S	-1.36	-2.68	1.32
220	C	C	4.73	5.79	-1.05
221	A	A	-1.19	-1.42	0.23
222	F	F	5.14	-2.88	8.02
223	C	C	-1.49	-2.48	0.99
224	K	K	0.87	2.99	-2.13
225	P	P	-2.96	-5.94	2.98
226	Q	Q	4.23	1.81	2.42
227	R	R	6.01	0.65	5.35
228	V	V	-1.63	-1.68	0.05
229	T	T	-1.18	0.11	-1.29
230	S	S	5.72	12.17	-6.45
231	V	V	0.52	0.05	0.47
232	I	I	3.9	4.19	-0.29
233	V	V	1.96	-4.88	6.84
234	E	E	10.02	-0.95	10.97
235	L	L	1.63	-4.55	6.18
236	E	E	1.92	-2.01	3.94
237	C	C	10.31	0.39	9.92
238	P	P	5.18	-0.08	5.25
239	G	G	2.39	-0.12	2.5
240	L	L	3.27	-1.77	5.04
241	D	D	17.28	2.22	15.05
242	P	P	9.09	-2.0	11.09
243	P	P	0.95	-5.4	6.35
244	F	F	-0.12	0.08	-0.2
245	R	R	1.97	-1.9	3.87
246	I	I	31.62	6.94	24.68
247	K	K	2.78	7.48	-4.69
248	K	K	16.35	7.38	8.97
249	I	I	-0.7	-3.32	2.63
250	Q	Q	1.87	-0.3	2.16
251	K	K	15.2	-1.77	16.97
252	V	V	-0.96	-4.74	3.78
253	K	K	4.85	2.92	1.93
254	H	H	-0.6	-2.2	1.6
255	C	C	-1.71	-2.48	0.77
256	R	R	-0.4	1.02	-1.42
257	C	C	-0.05	1.47	-1.52
258	M	M	2.9	1.6	1.3
259	S	-	-1.27	-	-
260	V	-	0.32	-	-
261	N	-	3.91	-	-
262	L	-	5.85	-	-
263	S	-	2.64	-	-
264	P	-	7.53	-	-
265	A	-	5.14	-	-
266	G	-	1.26	-	-
267	A	-	-1.23	-	-
268	I	-	0.54	-	-
269	P	-	17.53	-	-
270	S	S	1.73	2.98	-1.25
271	P	-	2.87	-	-
272	Y	-	1.1	-	-
273	K	-	3.45	-	-
274	W	-	12.61	-	-
275	H	-	6.13	-	-
276	H	-	1.9	-	-
277	Q	-	2.22	-	-
278	I	-	1.35	-	-
279	K	-	4.71	-	-
280	E	-	0.99	-	-
281	V	V	0.1	2.93	-2.83
282	L	-	-3.74	-	-
283	A	-	1.34	-	-
284	S	-	1.22	-	-
285	S	-	2.83	-	-
286	Q	-	3.1	-	-
287	E	-	5.43	-	-
288	A	-	4.18	-	-
289	-	X	-	5.09	-
290	-	X	-	-0.66	-
291	-	X	-	-1.2	-
292	-	X	-	-0.04	-
293	-	X	-	2.39	-
294	L	L	1.22	1.37	-0.15
295	V	V	-0.53	13.8	-14.33
296	V	V	-3.94	-1.09	-2.85
297	T	T	0.27	-0.39	0.66
298	E	E	-0.89	1.79	-2.68
299	R	R	-1.48	0.95	-2.43
300	K	K	4.85	0.89	3.96
301	Y	Y	2.33	-1.05	3.38
302	L	L	-1.57	14.69	-16.25
303	K	K	5.01	6.02	-1.0
304	S	S	4.01	-0.08	4.09
305	D	D	-0.37	3.14	-3.5
306	W	W	1.06	-2.12	3.18
307	C	C	1.87	-1.07	2.94
308	K	K	7.99	1.55	6.45
309	T	T	6.66	-0.48	7.14
310	Q	Q	4.25	-2.15	6.4
311	P	P	-0.32	14.02	-14.34
312	L	L	-2.47	193.13	-195.6
313	R	R	0.86	3.76	-2.91
314	Q	Q	1.99	1.77	0.23
315	T	T	-0.35	0.31	-0.67
316	V	V	-2.79	-5.39	2.6
317	S	S	0.47	1.23	-0.76
318	E	E	2.48	-0.98	3.46
319	E	E	7.52	4.78	2.74
320	G	G	3.18	-3.15	6.33
321	C	C	1.14	0.15	0.99
322	R	R	4.06	1.73	2.33
323	S	S	0.26	-0.8	1.06
324	R	R	3.29	1.91	1.38
325	T	T	-1.11	-0.18	-0.93
326	I	I	3.37	-0.8	4.17
327	L	L	6.78	0.18	6.61
328	N	N	-2.68	-3.83	1.15
329	R	R	9.22	-0.32	9.54
330	F	F	-3.41	85.02	-88.44
331	C	C	-1.75	-1.19	-0.56
332	Y	Y	-2.77	4.55	-7.32
333	G	G	-0.76	-3.07	2.31
334	Q	Q	-1.27	-2.85	1.57
335	C	C	-0.64	0.24	-0.88
336	N	N	-1.72	-2.09	0.37
337	S	S	-1.48	-2.65	1.17
338	F	F	-2.18	-3.22	1.04
339	Y	Y	-2.58	-2.62	0.04
340	I	I	-5.5	-1.87	-3.63
341	P	P	-3.62	-4.27	0.64
342	R	R	1.87	0.97	0.9
343	H	H	2.12	4.98	-2.86
344	V	V	4.35	-1.52	5.88
345	K	K	4.98	0.38	4.6
346	K	K	17.0	3.78	13.23
347	E	E	8.58	3.11	5.47
348	E	E	3.31	4.19	-0.88
349	D	D	3.63	3.93	-0.3
350	S	S	-1.8	0.85	-2.64
351	F	F	-2.37	1.08	-3.45
352	Q	Q	-0.05	-0.35	0.3
353	S	S	-1.1	1.91	-3.01
354	C	C	1.25	2.28	-1.02
355	A	A	-1.02	-1.6	0.58
356	F	F	1.7	-2.48	4.18
357	C	C	-2.06	-2.57	0.51
358	K	K	0.89	13.61	-12.72
359	P	P	-3.4	-6.31	2.91
360	Q	Q	6.09	1.74	4.34
361	R	R	19.03	9.88	9.16
362	V	V	1.89	-1.32	3.21
363	T	T	7.47	0.72	6.75
364	S	S	2.32	11.61	-9.29
365	V	V	-0.82	0.87	-1.7
366	I	I	0.83	0.97	-0.14
367	V	V	1.3	-5.48	6.77
368	E	E	9.84	-3.48	13.32
369	L	L	1.37	-5.02	6.39
370	E	E	3.79	-1.93	5.72
371	C	C	16.26	-0.12	16.38
372	P	P	8.83	-1.03	9.86
373	G	G	4.71	-0.16	4.87
374	L	L	10.4	-1.75	12.16
375	D	D	11.39	1.72	9.67
376	P	P	5.25	-1.99	7.24
377	P	P	0.49	-5.41	5.9
378	F	F	-0.12	-0.57	0.45
379	R	R	4.62	-0.84	5.46
380	I	I	4.42	10.99	-6.57
381	K	K	3.51	7.21	-3.7
382	K	K	2.85	7.84	-4.99
383	I	I	-0.1	-0.95	0.85
384	Q	Q	2.21	-0.89	3.1
385	K	K	15.56	-2.49	18.05
386	V	V	-3.51	-4.43	0.91
387	K	K	7.41	7.05	0.36
388	H	H	-0.25	-0.46	0.22
389	C	C	-1.77	-2.41	0.64
390	R	R	0.82	0.51	0.31
391	C	C	-0.27	1.64	-1.9
392	M	M	-1.3	0.1	-1.39
393	S	S	-1.99	2.19	-4.18
394	V	V	-0.97	3.56	-4.52
395	N	-	0.66	-	-
396	L	-	1.85	-	-
397	S	-	0.36	-	-
398	W	-	12.89	-	-
399	H	-	5.45	-	-
400	H	-	13.57	-	-
401	Q	-	4.32	-	-
402	I	-	6.3	-	-
403	-	X	-	0.41	-
404	-	X	-	0.22	-
405	-	X	-	0.21	-
406	-	X	-	1.69	-
407	K	K	4.26	9.18	-4.92
408	E	E	8.25	3.21	5.04
409	V	V	17.33	10.21	7.12
410	L	L	6.62	7.02	-0.4
411	A	A	2.53	9.2	-6.67
412	S	S	0.81	0.38	0.43
413	S	S	2.2	-2.41	4.62
414	Q	Q	3.73	21.9	-18.17
415	E	E	5.87	2.16	3.71
416	A	A	2.45	-1.25	3.7
417	L	L	3.59	262.7	-259.11
418	V	V	1.07	1.19	-0.12
419	V	V	-1.32	1.45	-2.76
420	T	T	1.8	2.06	-0.26
421	E	E	0.17	50.06	-49.89
422	R	R	2.01	-0.09	2.1
423	K	K	4.89	6.39	-1.51
424	Y	Y	-0.28	21.43	-21.72
425	L	L	1.38	0.1	1.27
426	K	K	15.4	8.28	7.12
427	S	S	4.63	1.55	3.08
428	D	D	-0.52	2.43	-2.95
429	W	W	1.94	-2.06	4.01
430	C	C	1.99	-0.92	2.91
431	K	K	10.75	-0.76	11.5
432	T	T	12.43	-0.82	13.25
433	Q	Q	3.08	0.1	2.98
434	P	P	0.51	1.19	-0.68
435	L	L	-4.26	1.17	-5.44
436	R	R	1.35	4.62	-3.27
437	Q	Q	4.31	-4.21	8.53
438	T	T	0.23	9.96	-9.72
439	V	V	-1.55	-4.99	3.44
440	S	S	12.59	-0.64	13.23
441	E	E	4.47	2.87	1.6
442	E	E	5.48	0.45	5.03
443	G	G	3.66	-2.21	5.87
444	C	C	14.86	0.37	14.49
445	R	R	19.33	0.99	18.34
446	S	S	19.78	-1.04	20.81
447	R	R	4.25	0.21	4.03
448	T	T	0.19	7.52	-7.33
449	I	I	6.27	-0.42	6.69
450	L	L	7.99	15.64	-7.65
451	N	N	-2.69	-3.33	0.64
452	R	R	19.41	2.22	17.19
453	F	F	-4.01	-4.01	0.01
454	C	C	-2.98	-1.28	-1.7
455	Y	Y	-2.93	-2.91	-0.02
456	G	G	-0.69	-2.5	1.81
457	Q	Q	-1.42	-3.22	1.8
458	C	C	-0.69	0.64	-1.34
459	N	N	-2.18	-1.27	-0.92
460	S	S	-2.28	-3.86	1.58
461	F	F	-1.52	-4.04	2.52
462	Y	Y	-1.37	-2.98	1.6
463	I	I	7.82	-2.54	10.36
464	P	P	-5.15	-2.67	-2.48
465	R	R	0.64	17.05	-16.41
466	H	H	2.79	10.56	-7.77
467	V	V	5.39	5.6	-0.21
468	K	K	18.12	10.47	7.65
469	K	K	17.91	2.84	15.07
470	E	E	15.4	2.5	12.9
471	E	E	1.12	3.59	-2.47
472	D	D	2.97	2.3	0.68
473	S	S	-1.81	-1.03	-0.79
474	F	F	0.97	-1.34	2.31
475	Q	Q	-1.43	-0.33	-1.1
476	S	S	-1.33	-2.14	0.81
477	C	C	5.1	2.05	3.05
478	A	A	-1.31	-1.48	0.17
479	F	F	5.44	14.05	-8.61
480	C	C	-1.42	-2.5	1.07
481	K	K	0.85	11.58	-10.73
482	P	P	-3.18	-5.74	2.56
483	Q	Q	4.3	9.17	-4.87
484	R	R	5.97	0.49	5.47
485	V	V	-1.63	17.31	-18.93
486	T	T	-1.22	-0.27	-0.94
487	S	S	2.37	10.95	-8.58
488	V	V	0.66	-0.43	1.09
489	I	I	1.42	1.64	-0.22
490	V	V	2.35	-3.58	5.93
491	E	E	19.92	0.08	19.84
492	L	L	45.29	-4.44	49.73
493	E	E	48.85	-0.28	49.14
494	C	C	46.84	5.51	41.33
495	P	P	13.8	2.3	11.5
496	G	G	6.13	3.01	3.12
497	L	L	8.72	7.68	1.04
498	D	D	16.06	11.37	4.69
499	P	-	7.98	-	-
500	P	P	2.13	10.59	-8.46
501	F	-	0.52	-	-
502	R	-	6.48	-	-
503	I	-	3.92	-	-
504	K	-	3.59	-	-
505	K	-	8.25	-	-
506	I	-	-0.28	-	-
507	Q	-	1.56	-	-
508	K	-	15.83	-	-
509	V	-	-1.37	-	-
510	K	-	4.83	-	-
511	H	-	-0.55	-	-
512	C	-	-1.69	-	-
513	R	-	1.08	-	-
514	C	-	6.38	-	-
515	M	-	13.57	-	-
516	S	-	-1.28	-	-
517	V	-	0.51	-	-
518	N	-	2.27	-	-
519	L	-	1.02	-	-
520	S	-	3.92	-	-
521	K	-	2.84	-	-
522	A	-	0.6	-	-
523	R	-	3.71	-	-
524	C	-	-1.67	-	-
525	S	-	-1.24	-	-
526	R	-	-2.67	-	-
527	K	-	-2.18	-	-
528	A	-	2.42	-	-
529	L	-	-1.04	-	-
530	H	-	3.19	-	-
531	V	-	-3.58	-	-
532	N	-	-2.31	-	-
533	F	-	-4.5	-	-
534	K	-	10.01	-	-
535	D	-	-1.4	-	-
536	M	-	1.07	-	-
537	G	-	-2.06	-	-
538	W	-	-6.25	-	-
539	D	-	3.09	-	-
540	D	-	-0.18	-	-
541	W	-	-2.03	-	-
542	I	-	1.74	-	-
543	I	-	-2.33	-	-
544	A	-	0.88	-	-
545	P	P	-2.05	37.58	-39.63
546	L	-	-0.51	-	-
547	E	-	-2.23	-	-
548	Y	-	-5.62	-	-
549	E	-	2.95	-	-
550	A	-	-1.8	-	-
551	F	-	4.17	-	-
552	H	-	4.09	-	-
553	C	-	-1.95	-	-
554	E	-	-0.43	-	-
555	G	-	-1.48	-	-
556	L	-	-0.85	-	-
557	C	-	2.58	-	-
558	E	-	0.43	-	-
559	F	F	2.81	2.65	0.17
560	P	-	-0.3	-	-
561	L	-	-0.47	-	-
562	R	-	11.68	-	-
563	S	-	1.29	-	-
564	H	-	6.29	-	-
565	L	-	8.96	-	-
566	E	-	14.43	-	-
567	P	-	2.39	-	-
568	T	-	-0.39	-	-
569	N	-	-0.94	-	-
570	H	-	-0.44	-	-
571	A	-	-1.57	-	-
572	V	-	-0.66	-	-
573	I	-	24.92	-	-
574	Q	-	-2.96	-	-
575	T	-	0.03	-	-
576	L	-	3.85	-	-
577	M	-	0.48	-	-
578	N	-	-0.87	-	-
579	S	-	-0.28	-	-
580	M	-	9.14	-	-
581	D	-	0.13	-	-
582	P	-	0.56	-	-
583	E	-	10.47	-	-
584	S	-	1.46	-	-
585	T	-	-0.73	-	-
586	P	-	0.7	-	-
587	P	-	-0.64	-	-
588	T	-	-1.49	-	-
589	C	-	3.4	-	-
590	C	-	-1.98	-	-
591	V	-	-1.38	-	-
592	P	-	-6.25	-	-
593	T	-	3.16	-	-
594	R	R	1.58	3.5	-1.92
595	L	-	-0.01	-	-
596	S	-	1.62	-	-
597	P	-	-0.36	-	-
598	I	-	4.08	-	-
599	S	-	0.09	-	-
600	I	-	5.62	-	-
601	L	-	-4.48	-	-
602	F	-	-4.83	-	-
603	I	I	7.86	4.22	3.64
604	D	-	-1.21	-	-
605	S	-	1.01	-	-
606	A	-	1.48	-	-
607	N	-	0.06	-	-
608	N	-	-2.09	-	-
609	V	-	-4.02	-	-
610	V	-	-0.54	-	-
611	Y	-	-2.32	-	-
612	K	-	-0.07	-	-
613	Q	-	4.18	-	-
614	Y	-	-4.24	-	-
615	E	-	2.18	-	-
616	D	-	-3.14	-	-
617	M	-	-3.76	-	-
618	V	-	-2.43	-	-
619	V	-	-4.81	-	-
620	E	-	1.28	-	-
621	S	-	-1.27	-	-
622	C	-	-2.08	-	-
623	G	-	-1.43	-	-
624	C	-	-1.83	-	-
625	R	-	0.94	-	-
626	K	-	2.73	-	-
627	A	-	0.71	-	-
628	R	-	11.32	-	-
629	C	-	-1.87	-	-
630	S	-	-1.25	-	-
631	R	-	-2.64	-	-
632	K	K	-2.15	0.23	-2.38
633	A	-	2.51	-	-
634	L	-	-0.94	-	-
635	H	-	3.13	-	-
636	V	-	-3.69	-	-
637	N	-	-2.35	-	-
638	F	-	-4.48	-	-
639	K	K	9.94	5.53	4.41
640	D	-	-0.66	-	-
641	M	-	0.42	-	-
642	G	-	-2.03	-	-
643	W	-	-6.41	-	-
644	D	-	2.91	-	-
645	D	-	0.0	-	-
646	W	-	-2.2	-	-
647	I	-	1.63	-	-
648	I	-	-2.35	-	-
649	A	-	0.76	-	-
650	P	-	-2.46	-	-
651	L	-	-0.36	-	-
652	E	-	-2.38	-	-
653	Y	-	-5.76	-	-
654	E	-	2.88	-	-
655	A	-	-1.52	-	-
656	F	-	4.31	-	-
657	H	-	4.2	-	-
658	C	-	-1.96	-	-
659	E	-	-0.47	-	-
660	G	-	-1.47	-	-
661	L	-	-0.6	-	-
662	C	-	2.8	-	-
663	E	-	1.1	-	-
664	F	-	2.47	-	-
665	P	-	-0.19	-	-
666	L	-	36.79	-	-
667	R	-	16.31	-	-
668	S	-	21.14	-	-
669	H	-	27.62	-	-
670	L	-	165.43	-	-
671	E	-	9.11	-	-
672	P	-	29.99	-	-
673	T	-	-0.25	-	-
674	N	-	1.0	-	-
675	H	-	-0.55	-	-
676	A	-	-1.43	-	-
677	V	-	-0.69	-	-
678	I	-	11.93	-	-
679	Q	-	-2.84	-	-
680	T	-	-0.88	-	-
681	L	-	5.0	-	-
682	M	-	0.39	-	-
683	N	-	-0.66	-	-
684	S	-	-0.2	-	-
685	M	-	9.11	-	-
686	D	-	-0.12	-	-
687	P	-	0.31	-	-
688	E	-	3.72	-	-
689	S	-	1.36	-	-
690	T	-	-0.52	-	-
691	P	-	1.41	-	-
692	P	-	0.13	-	-
693	T	-	-1.42	-	-
694	C	-	3.38	-	-
695	C	-	-2.01	-	-
696	V	-	-1.14	-	-
697	P	-	-5.97	-	-
698	T	-	4.56	-	-
699	R	-	1.85	-	-
700	L	-	-0.19	-	-
701	S	-	1.94	-	-
702	P	-	0.32	-	-
703	I	-	4.05	-	-
704	S	-	-0.12	-	-
705	I	-	5.66	-	-
706	L	-	-4.37	-	-
707	F	-	-4.77	-	-
708	I	I	8.17	-1.81	9.98
709	D	-	-1.39	-	-
710	S	-	0.98	-	-
711	A	-	1.41	-	-
712	N	-	0.34	-	-
713	N	-	-2.04	-	-
714	V	-	-3.72	-	-
715	V	-	0.98	-	-
716	Y	-	-3.91	-	-
717	K	-	-0.52	-	-
718	Q	Q	1.54	-0.64	2.18
719	Y	-	-4.03	-	-
720	E	-	2.17	-	-
721	D	-	-3.21	-	-
722	M	-	-3.85	-	-
723	V	-	-2.22	-	-
724	V	-	-4.71	-	-
725	E	-	1.23	-	-
726	S	-	-1.28	-	-
727	C	-	-1.46	-	-
728	G	-	113.14	-	-
729	C	-	36.23	-	-
730	R	-	4.62	-	-
731	K	-	7.18	-	-
732	A	-	0.63	-	-
733	R	-	3.81	-	-
734	C	-	-1.84	-	-
735	S	-	-1.15	-	-
736	R	-	-2.7	-	-
737	K	K	-2.18	0.93	-3.11
738	A	-	2.27	-	-
739	L	-	-1.1	-	-
740	H	-	3.28	-	-
741	V	V	-3.63	-5.05	1.42
742	N	-	-1.98	-	-
743	F	-	-4.2	-	-
744	K	K	9.58	11.21	-1.64
745	D	-	-1.35	-	-
746	M	-	0.1	-	-
747	G	-	-1.41	-	-
748	W	-	-1.83	-	-
749	D	-	3.12	-	-
750	D	-	0.29	-	-
751	W	-	2.3	-	-
752	I	-	2.46	-	-
753	I	-	-0.92	-	-
754	A	-	2.53	-	-
755	P	-	0.62	-	-
756	L	-	1.4	-	-
757	E	-	-1.05	-	-
758	Y	-	-5.78	-	-
759	E	-	2.98	-	-
760	A	-	-1.77	-	-
761	F	-	4.43	-	-
762	H	-	4.13	-	-
763	C	-	-1.95	-	-
764	E	-	-0.48	-	-
765	G	-	-1.44	-	-
766	L	-	-1.86	-	-
767	C	-	2.57	-	-
768	E	-	0.12	-	-
769	F	-	-0.46	-	-
770	P	-	-1.65	-	-
771	L	-	-0.76	-	-
772	R	-	4.74	-	-
773	S	-	0.58	-	-
774	H	-	6.94	-	-
775	L	-	2.61	-	-
776	E	-	12.46	-	-
777	P	-	0.34	-	-
778	T	-	-0.58	-	-
779	N	-	-3.68	-	-
780	H	H	-0.4	-0.07	-0.33
781	A	-	-1.37	-	-
782	V	-	4.22	-	-
783	I	-	11.03	-	-
784	Q	-	-2.98	-	-
785	T	-	0.05	-	-
786	L	-	3.31	-	-
787	M	-	0.83	-	-
788	N	-	-0.73	-	-
789	S	-	-0.49	-	-
790	M	-	9.64	-	-
791	D	-	-0.47	-	-
792	P	-	-0.35	-	-
793	E	-	9.65	-	-
794	S	-	1.42	-	-
795	T	-	-1.41	-	-
796	P	-	2.31	-	-
797	P	-	2.32	-	-
798	T	-	-1.31	-	-
799	C	-	3.24	-	-
800	C	-	-2.05	-	-
801	V	-	-0.14	-	-
802	P	-	-4.36	-	-
803	T	-	5.05	-	-
804	R	-	6.01	-	-
805	L	-	-0.06	-	-
806	S	-	1.61	-	-
807	P	-	-0.25	-	-
808	I	-	3.97	-	-
809	S	-	0.21	-	-
810	I	-	5.95	-	-
811	L	-	-1.64	-	-
812	F	-	-3.98	-	-
813	I	-	9.19	-	-
814	D	-	-1.03	-	-
815	S	-	1.1	-	-
816	A	-	1.48	-	-
817	N	-	-0.54	-	-
818	N	-	-0.96	-	-
819	V	-	0.96	-	-
820	V	-	-0.37	-	-
821	Y	-	0.7	-	-
822	K	-	0.81	-	-
823	Q	-	0.81	-	-
824	Y	-	-2.06	-	-
825	E	-	6.3	-	-
826	D	-	-3.22	-	-
827	M	-	-2.84	-	-
828	V	-	-2.12	-	-
829	V	-	-5.01	-	-
830	E	-	1.53	-	-
831	S	-	1.72	-	-
832	C	-	-2.08	-	-
833	G	-	-1.17	-	-
834	C	-	-0.95	-	-
835	R	-	4.97	-	-
836	K	-	7.2	-	-
837	A	-	0.61	-	-
838	R	-	3.84	-	-
839	C	C	-1.83	-2.14	0.31
840	S	-	-1.18	-	-
841	R	R	-2.47	0.39	-2.86
842	K	-	-2.17	-	-
843	A	-	2.08	-	-
844	L	-	-1.14	-	-
845	H	-	3.19	-	-
846	V	-	-3.68	-	-
847	N	-	-2.07	-	-
848	F	-	-4.33	-	-
849	K	-	9.99	-	-
850	D	-	-1.41	-	-
851	M	-	1.15	-	-
852	G	-	-1.47	-	-
853	W	-	-1.62	-	-
854	D	-	3.06	-	-
855	D	-	0.31	-	-
856	W	-	2.29	-	-
857	I	-	2.54	-	-
858	I	-	-0.96	-	-
859	A	-	2.61	-	-
860	P	-	0.58	-	-
861	L	-	1.6	-	-
862	E	-	-0.96	-	-
863	Y	-	-5.72	-	-
864	E	-	2.92	-	-
865	A	-	-1.7	-	-
866	F	-	4.45	-	-
867	H	-	4.11	-	-
868	C	-	-1.97	-	-
869	E	-	-0.44	-	-
870	G	-	-1.48	-	-
871	L	-	-1.92	-	-
872	C	C	2.64	1.26	1.38
873	E	-	0.1	-	-
874	F	-	0.08	-	-
875	P	-	-1.37	-	-
876	L	-	-1.09	-	-
877	R	-	4.9	-	-
878	S	-	0.37	-	-
879	H	-	7.08	-	-
880	L	-	2.68	-	-
881	E	-	14.43	-	-
882	P	-	2.46	-	-
883	T	-	-0.42	-	-
884	N	-	-3.75	-	-
885	H	-	-0.32	-	-
886	A	-	-1.57	-	-
887	V	-	5.28	-	-
888	I	-	23.11	-	-
889	Q	-	-2.94	-	-
890	T	-	0.01	-	-
891	L	-	3.27	-	-
892	M	-	0.76	-	-
893	N	-	-0.54	-	-
894	S	-	0.02	-	-
895	M	M	9.72	10.26	-0.54
896	D	-	-0.04	-	-
897	P	-	0.04	-	-
898	E	-	10.35	-	-
899	S	-	1.38	-	-
900	T	-	-1.07	-	-
901	P	-	1.67	-	-
902	P	-	1.16	-	-
903	T	-	-1.31	-	-
904	C	-	3.16	-	-
905	C	-	-2.06	-	-
906	V	-	-1.28	-	-
907	P	-	-6.11	-	-
908	T	-	2.52	-	-
909	R	-	9.69	-	-
910	L	-	0.54	-	-
911	S	-	3.58	-	-
912	P	-	0.1	-	-
913	I	-	3.79	-	-
914	S	-	0.0	-	-
915	I	-	6.14	-	-
916	L	-	-1.55	-	-
917	F	-	-3.94	-	-
918	I	-	9.24	-	-
919	D	-	-0.8	-	-
920	S	S	1.12	-0.06	1.19
921	A	-	1.36	-	-
922	N	-	3.34	-	-
923	N	-	-1.04	-	-
924	V	-	0.76	-	-
925	V	-	-0.62	-	-
926	Y	-	0.74	-	-
927	K	-	0.82	-	-
928	Q	-	0.94	-	-
929	Y	-	-2.18	-	-
930	E	-	7.04	-	-
931	D	-	-3.0	-	-
932	M	-	-2.88	-	-
933	V	-	-2.72	-	-
934	V	V	-4.74	16.77	-21.51
935	E	-	6.4	-	-
936	S	-	-1.15	-	-
937	C	-	-2.12	-	-
938	G	-	-1.19	-	-
939	C	-	-1.19	-	-
940	R	-	1.5	-	-
941	-	X	-	5.02	-
942	-	X	-	-0.23	-
943	-	X	-	12.31	-

Analysis of pair 5hk5H_4jphB

Figure 1: Two structures (Fold1 & Fold2)

Figure 2: Two structures aligned

Figure 3: Deep-MSA contact map panel

Figure 4: Best clusters contact map panel

Figure 5: All clusters contact-map mosaic (small multiples).

Per-cluster contact maps

Figure 6: Aligned per-residue ΔΔG (seq alignment overlay).

Figure 7: Phylogenetic tree with per-cluster heatmap.

Cluster metrics table

Aligned per-residue ΔΔG